SLITRK6 CHO
CBP74486
詢(xún) 價(jià)
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產(chǎn)品描述
產(chǎn)品數(shù)據(jù)庫(kù)
| I. Background | |
| SLITRK6(SLIT and NTRK like family member 6)是一種屬于 SLITRK 家族的基因, 主要在神經(jīng)系統(tǒng)中表達(dá),尤其在成人腦部的紋狀體(putamen)中高度表達(dá),而在大腦皮層 無(wú)表達(dá);它也存在于成年和胎兒肺組織及胎兒肝臟中。該基因編碼的蛋白包含多個(gè)亮氨酸 富集重復(fù)區(qū)(LRR),參與神經(jīng)突觸發(fā)育與調(diào)控,能抑制神經(jīng)突起生長(zhǎng),并在內(nèi)耳神經(jīng)回 路發(fā)育中起關(guān)鍵作用。研究表明,SLITRK6 基因突變可能與聽(tīng)力障礙和視力問(wèn)題相關(guān),例 如有病例顯示其純合突變可能導(dǎo)致重度耳聾。此外,在男性性取向的研究中,SLITRK6 基 因也被發(fā)現(xiàn)存在差異,提示其可能影響大腦下丘腦區(qū)域的激素調(diào)控。目前,該基因已成為 神經(jīng)發(fā)育、聽(tīng)覺(jué)疾病及行為遺傳學(xué)研究的重要靶點(diǎn)。 | |
| II. Description | |
| SLITRK6 CHO 細(xì)胞,在 CHO-K1 細(xì)胞的基礎(chǔ)上,穩(wěn)定表達(dá)人 SLITRK6。 | |
| III. Introduction | |
| Expressed gene: | SLITRK6 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+5 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| IV. Representative Data | |
![]() Figure 1. Recombinant SLITRK6 CHO stably expressing SLITRK6.
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