CSF3R T618I/BaF3
CBP73253
詢 價(jià)
留 言
產(chǎn)品描述
產(chǎn)品數(shù)據(jù)庫
| I. Introduction | |
|
Cell Line Name： |
CSF3R T618I/BaF3 |
|
Host Cell: |
Ba/F3 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
|
Application: |
Anti-proliferation assay and PD assay |
|
Freeze Medium: |
90% FBS+10% DMSO |
|
Complete Culture Medium: |
RPMI-1640+10%FBS |
|
Mycoplasma Status: |
Negative |
| II. Background | |
|
CSF3R T618I lies within the extracellular domain proximal to the transmembrane domain of the Csf3r protein (PMID: 23656643). T618I confers a gain of function to the Csf3r protein as demonstrated by increased proliferation and increased downstream Jak-Stat signaling in transformed cells in culture (PMID: 23656643). |
|
| III. Representative Data | |
|
1.WB of CSF3R T618I/BaF3
|
|
|
2. Anti-proliferation assay
Figure 2. Anti-proliferation assay of three reference compounds on the CSF3R T618I/BaF3. |
|
